1. Historical review. - 1. Introduction. - 2. József Marek and the first description of Marek's disease. - 3. Classical studies 19201939. - 4. The middle period 19401959. - 5. Events since 1960. - 2. Clinical disease and its economic impact. - 1. Introduction. - 2. Occurrence of infection and disease. - 3. The disease during production. - 4. The disease at slaughter. - 5. Economic loss from disease. - 6. Conclusions. - 3. Pathology. - 1. Introduction. - 2. Gross appearances. - 3. Histopathological and ultrastructural appearances. - 4. Lymphoma-derived cell lines. - 5. Transplantable lymphomas. - 6. Factors affecting pathogenesis. - 4. Characteristics of the virus. - 1. Introduction. - 2. Virus strains. - 3. Physical and chemical properties. - 4. Isolation and cultivation. - 5. Virus replication. - 6. Viral antigens. - 7. Concluding remarks. - 5. Molecular biology of the virus. - 1. Introduction. - 2. Viral deoxyribonucleic acid. - 3. Viral proteins. - 4. Replication. - 5. Oncogenesis. - 6. Concluding remarks. - 6. Laboratory diagnosis. - 1. Introduction. - 2. Diagnosis of a field outbreak. - 3. Diagnosis of infection. - 7. Immunity. - 1. Introduction. - 2. Expression of impunity. - 3. Immune responses to Marek's disease-associated antigens. - 4. Contribution of immune responses to the expression of immunity. - 5. Immunosuppression. - 8. Principles of vaccination. - 1. Introduction. - 2. Types of vaccine. - 3. Responses to vaccination. - 4. Mechanisms of protection. - 5. Factors affecting vaccine efficacy. - 6. Investigation of vaccine failures. - 7. Comparative efficacy of vaccines. - 8. Strategies and perspectives. - 9. Production of vaccines. - 1. Introduction. - 2. Production methods. - 3. Conclusion. - 10. Quality control and standardization of vaccines. - 1. Introduction. - 2. Safety. - 3. Efficacy. - 4. Purity. -5. Standard preparations. - 6. Recommended tests. - 11. Genetic resistance. - 1. Significance and historical aspects of genetic resistance. - 2. Expression of resistance. - 3. Mechanism of genetic resistance. - 12. Spread of Marek's disease. - 1. Introduction. - 2. Spread of infection. - 3. Flock infection. - 4. Factors affecting the incidence of Marek's disease. - 13. Control of Marek's disease by the poultry industry: practical considerations. - 1. Introduction. - 2. Control by hygiene. - 3. Breeding for resistance. - 4. Control by vaccination. Language: English