I. Overview of Physiology of the GHRH-Somatostatin-GH-IGF-I Axis. - 1. Physiology of the Growth Hormone Releasing Hormone-Somatostatin-Growth Hormone-Insulin-Like Growth Factor I Axis. - 2. Role of Somatostatin in the Regulation of Growth Hormone Secretion. - 3. Growth Hormone Releasing Hormone and Growth Hormone Releasing Peptides. - 4. GH Binding Protein GH Receptors and Domains Involved in Signal Transduction. - 5. Insulin-Like Growth Factors During Development. - II. Effects of Recombinant Human GH and/or IGF-I in Catabolic Illness. - 6. Anabolic Effects of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Human Disease. - 7. Growth Hormone in Children with Chronic Renal Disease: Some Metabolic Considerations. - 8. Growth Hormone: The Visible Difference in Burn Care. - 9. Effects of Recombinant Human Growth Hormone on Body Composition and Metabolism in HIV-Associated Wasting. - 10. Administration of Growth Hormone as an Adjunct to Nutritional Support in Critical Illness. - 11. Strategies for the Use of Recombinant Human Growth Hormone and Insulin-Like Growth Factor I in Amyotrophic Lateral Sclerosis. - III. Contemporary Issues in Growth and Development. - 12. Contemporary Issues in Growth and Development: An Overview. - 13. Use of Recombinant IGF-I in Syndromes of GH Insensitivity. - 14. Use of Growth Hormone in Non-Growth-Hormone-Deficient Children: Physiologic Pharmacologic and Ethical Issues. - 15. Growth Hormone Treatment of Nonelderly Adults with GH Deficiency. - IV. Effects of rhGH and IGF-I on Intermediary and Bone Metabolism. - 16. Overview of Growth Hormone and IGF-I Effects on Intermediary Metabolism and Bone. - 17. Effects of rhGH on Glucose Lipid and Amino Acid Metabolism. - 18. Metabolic Effects of IGF-I: Implications for the Therapy of Diabetes Mellitus. - 19. Modulation of Responses to GH and IGF-I by Nutritional Variables. - 20. Growth Hormone Effects on the Adult Skeleton. - 21. Insulin-Like Growth Factors and Skeletal Remodeling. - V. Use of GHRH rhGH and rhIGF-I in Aging. - 22. Growth Hormone and Aging: A Brief Review. - 23. Potential Benefits and Risks in Treating the Hyposomatomedinemia and Hypogonadism of Elderly Men. - 24. Effects of Growth Hormone Releasing Hormone Administration in Healthy Aging Men. - 25. Effects of Recombinant Human Insulin-Like Growth Factor I in Aging. - 26. Growth Hormone and Immune Function in the Elderly. - 27. Treatment with Growth Hormone: Focus on Specificity with a View to the Future. - Author Index. Language: English